The Rnits package for normalization and inference of di erential expression in time series microarray data
نویسنده
چکیده
2 Method 2 2.1 Data preprocessing and normalization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.2 B-spline basis model based hypothesis testing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.3 Clustering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.4 Candidate model evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.5 Model Selection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
منابع مشابه
A New Modified Histogram Matching Normalization for Time Series Microarray Analysis
Microarray data is often utilized in inferring regulatory networks. Quantile normalization (QN) is a popular method to reduce array-to-array variation. We show that in the context of time series measurements QN may not be the best choice for this task, especially not if the inference is based on continuous time ODE model. We propose an alternative normalization method that is better suited for ...
متن کاملبه کارگیری روشهای خوشهبندی در ریزآرایه DNA
Background: Microarray DNA technology has paved the way for investigators to expressed thousands of genes in a short time. Analysis of this big amount of raw data includes normalization, clustering and classification. The present study surveys the application of clustering technique in microarray DNA analysis. Materials and methods: We analyzed data of Van’t Veer et al study dealing with BRCA1...
متن کاملClassification and Biomarker Genes Selection for Cancer Gene Expression Data Using Random Forest
Background & objective: Microarray and next generation sequencing (NGS) data are the important sources to find helpful molecular patterns. Also, the great number of gene expression data increases the challenge of how to identify the biomarkers associated with cancer. The random forest (RF) is used to effectively analyze the problems of large-p and smal...
متن کاملExtracellular exosomes and preeclampsia: a microarray-based study and functional enrichment analysis
Background: Preeclampsia (PE) is a heterogeneous pregnancy disease which the exact pathophysiology of it is unknown. Recently exosomes have been indicated as a causative factor in the pathogenesis of PE. The aim of the study was to investigate in microarray library data to extract the differentially expressed genes (DEGs) in PE and to perform a functional enrichment analysis to predict the rol...
متن کاملNumerical Solution of fuzzy differential equations of nth-order by Adams-Bashforth method
So far, many methods have been presented to solve the rst-order di erential equations. But, not many studies have been conducted for numerical solution of high-order fuzzy di erential equations. In this research, First, the equation by reducing time, we transform the rst-order equation. Then we have applied Adams-Bashforth multi-step methods for the initial approximation of one order di erentia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016